Table 1.
human γδ T cell ligands
| Subset | Antigen | Reference(s) | |
|---|---|---|---|
| Vγ1.3Vδ2 | Histidyl-tRNA synthetase | (51) | |
| Vγ4Vδ5 | Endothelial protein C receptor (EPCR) | (52) | |
| Vγ9Vδ2 | Alkylamines | (53) | |
| Phosphoantigens (pAgs) | Butyrophilin 3A1 (BTN3A1)+ Pyrophosphate molecules |
(38) | |
| (E)-4-hydroxy-3-methyl- but-2-enyl pyrophosphate (HMBPP) |
(54) | ||
| Isopentenyl pyrophosphate (IPP) |
(55) | ||
| Bromohydrin pyrophosphate (BrHPP) |
(56) | ||
| Endogenous mevalonate metabolites |
(57) | ||
| Agonistic monoclonal antibody (called 20.1) |
(58) | ||
| Surface mitochondrial F1-ATPase-related structure/Apolipoprotein A-I |
(59, 60) | ||
| ULBP4(a soluble isoform of RAET1E) |
(61) | ||
| Ligands on Daudi & Molt-4 cell lines |
(62, 63) | ||
| Human MutS homolog | (64) | ||
| Vδ1 | Lipohexapeptides | (65) | |
| CD1c–expressing cells | (66) | ||
| Vγ2Vδ8(clone) | HSV glycoprotein I | (67) | |
| Vδ1 (IELs) | MICA & MICB | (25, 68) | |
| Vδ1 (blood γδ T cells) | CD1d–sulphatide | (69) | |
| CD1d-α-GalCer | (70) | ||
| Various | Phycoerythrin | (71) | |
HSV, herpes simplex virus; MICA, MHC class I polypeptide-related sequence A; MICB, MHC class I polypeptide-related sequence B; RAET1E, Retinoic acid early transcript 1E, ULBP4, UL16-binding protein4