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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: Nature. 2016 Aug 25;536(7617):474–478. doi: 10.1038/nature18952

Figure 2. Protective efficacy of DNA vaccines.

Figure 2

(a) Balb/c mice (N=5 or 10/group) received a single immunization by the i.m. route with 50 µg full-length prM-Env DNA vaccine or a sham vaccine and were challenged at week 4 by the i.v. route with 105 VP (102 PFU) ZIKV-BR or ZIKV-PR. Serum viral loads are shown. (b) Mice (N=5/group) received a single immunization with 50 µg of various DNA vaccines and were challenged with ZIKV-BR. Correlates of (c) protective efficacy and (d) day 3 viral loads are shown. Red bars reflect medians. P-values reflect t-tests and Spearman rank-correlation tests.