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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: Nature. 2016 Aug 25;536(7617):474–478. doi: 10.1038/nature18952

Figure 4. Immunogenicity and protective efficacy of PIV vaccine.

Figure 4

Balb/c mice (N=5/group) received a single immunization by the i.m. or s.q. route with 1 µg PIV vaccine with alum or alum alone and were challenged at week 4 by the i.v. route with 105 VP (102 PFU) ZIKV-BR. (a) Humoral immune responses were assessed at week 3 following vaccination by Env-specific ELISA. (b) Correlates of protective efficacy. (c) Serum viral loads are shown following ZIKV-BR challenge. Red bars reflect medians. P-values reflect t-tests.