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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: Nature. 2016 Aug 25;536(7617):474–478. doi: 10.1038/nature18952

Extended Data Figure 4. Immunogenicity and protective efficacy of prM-Env DNA vaccine in SJL mice.

Extended Data Figure 4

SJL mice (N=5/group) received a single immunization by the i.m. route with 50 µg full-length prM-Env DNA vaccine or a sham vaccine and were challenged at week 4 by the i.v. route with 105 VP (102 PFU) ZIKV-BR. Humoral immune responses were assessed at week 3 following vaccination by Env-specific ELISA (top). Red bars reflect medians. Serum viral loads are shown following ZIKV-BR challenge (bottom).