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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: Brain Res. 2016 Apr 26;1647:94–104. doi: 10.1016/j.brainres.2016.04.020

Figure 1. Model for rapid antidepressant activation of homeostatic mechanisms.

Figure 1

(A) MDD leads to a network that is outside of the ideal homeostatic range, as indicated by the out of balance scale. (B) NMDAR antagonists (green circle) pushes the network further outside the ideal range activating homeostatic mechanisms (C) that result in relief from MDD and remission (D).