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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Immunogenetics. 2016 Jul 1;68(8):677–691. doi: 10.1007/s00251-016-0932-z

Figure 3. Proposed roles of non-classical CD8+ αβ T cell populations in humans and mice, compared to conventional CD8+ T cells.

Figure 3

A) MHC class Ib-restricted CD8+ T cells, e.g. iNKT cells and MAIT cells, have a faster effector response following infection, compared to MHC class Ia-restricted T cells. B) During chronic infection, microorganisms can employ immunoevasion mechanisms to dampen the classical T cell response and/or NK cell response. MHC class Ib-specific responses could represent a backup system that responds following MHC class Ib upregulation, for example HLA-E.