Table 2.
The antimicrobial response of MHC class Ib-restricted T cells in mice and humans
| T cell | Positive Selection | Recognized Antigens | PIZF | Cytokine Prolife |
|---|---|---|---|---|
| Group 1 CD 1-restricted T cells | HC | Mtb lipids | Yes | IFN-γ, TNF-α, IL-6, IL-13 |
| Type I NKT cells | HC | α-Galcer, microbial lipids | Yes | IFN-γ, TNF-α, IL-4, IL-13, IL-17 etc. |
| Type II NKT cells | HC | Sulfatide, glycolipids and phospholipids | Yes | IFN-γ, TNF-α, IL-17 |
| MAIT cells | HC | Bacterial and fungal riboflavin metabolites | Yes | IFN-γ, TNF-α, IL-2, IL-17 |
| HFE-restricted T cells | ND | N/A | No | IL-6, IL-10, hepcidin |
| M3-restricted T cells | HC or TEC | Bacterial and fungal N-formylatcd peptides | No | IFN-γ , TNF-α |
| Qa-1/HLA-E-restricted T cells | HC or TEC | CMV- and GroEL-derived peptides | ND | IFN-γ, TNF-α, IL-4, IL-5, IL-10, IL-13 |
| TL-restricted T cells | ND | N/A | ND | IFN-γ |
| Q9-restricted T cells | ND | MPyV-derived peptide | ND | IFN-γ, TNF-α |
| HLA-G-restricted T cells | ND | HCMV-derived peptide | ND | ND |
HC: hematopoietic cell; TEC: thymic epithelial cell; ND; no data