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One agent, Single endpoint (DLT)
Next recommended dose is the dose having a mean posterior probability of DLT closest to 30%
3 participants by cohort, dose skipping allowed (limited to 200mg)
| Cohort | Dose (mg) | Number of observed DLT | Next dose level proposed (mg) |
|---|---|---|---|
|
| |||
| 1 | 100 | 0 | 300 |
| 1 | 200 | ||
| 2 | 50 | ||
| 3 | 50 | ||
|
| |||
| 2 (0 DLT in cohort 1) | 300 | 0 | 500 |
| 1 | 500 | ||
| 2 | 300 | ||
| 3 | 100 | ||
|
| |||
| 3 (0 DLT in cohort 1 and 2) | 500 | 0 | 700 |
| 1 | 600 | ||
| 2 | 500 | ||
| 3 | 400 | ||
|
| |||
| 4 (0 DLT in cohort 1, 2 and 3) | 700 | 0 | 900 |
| 1 | 800 | ||
| 2 | 700 | ||
| 3 | 600 | ||
