Table 2.
EAT versus SAT | ||||||
---|---|---|---|---|---|---|
Gene name | Fold Change | P value | FDR | Mean Expression | ||
EAT (n = 11) |
SAT (n = 11) |
|||||
Enriched in EAT | ITLN1 | 34.8 | <0.001 | 0.011 | 1726 ± 1559 | 50 ± 11 |
CCL21 | 11.1 | <0.001 | 0.007 | 5633 ± 3157 | 506 ± 346 | |
KCNN3 | 2.47 | <0.001 | 0.007 | 180 ± 47 | 73 ± 10 | |
PLA2G2A | 2.23 | 0.001 | 0.020 | 855 ± 341 | 384 ± 214 | |
PLAT | 1.84 | <0.001 | 0.011 | 1037 ± 302 | 563 ± 184 | |
KCNA3 | 1.65 | 0.004 | 0.049 | 265 ± 87 | 161 ± 53 | |
KCNK17 | 1.57 | <0.001 | 0.007 | 124 ± 22 | 79 ± 7 | |
CXCR5 | 1.31 | 0.001 | 0.017 | 42 ± 9 | 32 ± 3 | |
CCR2 | 1.43 | 0.002 | 0.030 | 127 ± 25 | 89 ± 20 | |
ADORA1 | 1.16 | 0.044 | 0.238* | 96 ± 16 | 82 ± 13 | |
Enriched in SAT | MAOB | 2.73 | <0.001 | 0.007 | 318 ± 102 | 870 ± 158 |
LOXL2 | 2.02 | <0.001 | 0.007 | 230 ± 52 | 467 ± 124 | |
LOXL4 | 1.63 | <0.001 | 0.007 | 138 ± 20 | 226 ± 43 | |
SMAD7 | 1.51 | 0.003 | 0.038 | 206 ± 64 | 312 ± 78 | |
USP30 | 1.43 | <0.001 | 0.007 | 168 ± 27 | 240 ± 33 | |
USP14 | 1.31 | <0.001 | 0.007 | 839 ± 98 | 1099 ± 166 | |
SOD1 | 1.31 | <0.001 | 0.007 | 1337 ± 198 | 1747 ± 206 | |
SMAD2 | 1.23 | <0.001 | 0.011 | 727 ± 70 | 897 ± 94 | |
TGFBR3 | 1.19 | 0.003 | 0.042 | 1775 ± 221 | 2120 ± 247 | |
SMURF1 | 1.17 | 0.003 | 0.038 | 487 ± 69 | 572 ±39 | |
EATCAD versus EATVal | ||||||
EATCAD (n = 6) |
EATVal (n = 5) |
|||||
Enriched in EATCAD | TECRL | 14.6 | 0.022 | 0.999* | 147 ± 331 | 10 ± 1 |
CTSE | 2.51 | 0.034 | 0.999* | 247 ± 144 | 98 ± 44 | |
FLRT3 | 2.48 | 0.005 | 0.999* | 182 ± 111 | 74 ± 30 | |
TRDN | 2.43 | 0.028 | 0.999* | 139 ± 92 | 58 ± 23 | |
HSPB7 | 2.25 | 0.005 | 0.925* | 722 ± 183 | 321 ± 160 | |
Enriched in EAT-Val | O3FAR1 | 1.73 | <0.001 | 0.114* | 159 ± 25 | 274 ± 58 |
CD33 | 1.73 | <0.001 | 0.114* | 233 ± 49 | 402 ± 75 | |
ENG | 1.35 | <0.001 | 0.114* | 1431 ± 204 | 1927 ± 312 | |
CLEC9A | 1.28 | <0.001 | 0.114* | 22 ± 1 | 28 ± 6 | |
MAP3K1 | 1.22 | <0.001 | 0.114* | 834 ± 76 | 1019 ± 123 |
The signal intensity for each individual gene was measured by microarray and analyzed using GenePattern differential analysis. Expression data are presented as mean ± SD. A 2-sided student’s t-test of paired samples was used to calculate p-values in GenePattern as 2signal(EAT-SAT) or 2signal(EATCAD-EATVal). Select genes from this differential analysis are listed with their p-values, FDR and fold changes.
indicates genes with an FDR ≥5% that were included to facilitate discussion.