Table 4.

Significantly enriched gene sets in EATCAD versus EATVal.

Enriched in EAT of CAD patients compared to EAT of valve patients at nominal p value < 1%
GO ID	GO term	Genes with core enrichment	Total # genes in set	ES	NES	NOM p-val	FDR q-val
GO:0050906	Detection of stimulus involved in sensory perception	7	21	0.57	1.79	0.008	0.306
Enriched in EAT of valve patients compared to EAT of CAD patients at nominal p value < 1%
GO:0030166	Proteoglycan biosynthetic process	4	15	−0.71	−1.85	<0.001	0.265
GO:0008080	N acyltransferase activity	12	21	−0.59	−1.74	<0.001	0.226
GO:0008270	Zinc ion binding	22	85	−0.43	−1.65	<0.001	0.399
GO:0016044	Membrane organization and biogenesis	50	130	−0.40	−1.59	<0.001	0.504
GO:0046914	Transition metal ion binding	23	105	−0.35	−1.47	0.002	0.53
GO:0051128	Regulation of cellular component organization and biogenesis	41	116	−0.38	−1.58	0.004	0.473
GO:0051347	Positive regulation of transferase activity	29	84	−0.4	−1.43	0.004	0.585
GO:0006984	ER nuclear signaling pathway	8	16	−0.6	−1.78	0.006	0.273
GO:0008234	Cysteine type peptidase activity	20	53	−0.52	−1.77	0.006	0.238
GO:0008144	Drug binding	7	15	−0.51	−1.7	0.006	0.314
GO:0006508	Proteolysis	62	181	−0.39	−1.61	0.006	0.466
GO:0004197	Cysteine type endopeptidase activity	15	39	−0.53	−1.76	0.008	0.223
GO:0006944	Membrane fusion	14	28	−0.61	−1.7	0.008	0.3
GO:0016540	Protein autoprocessing	11	31	−0.55	−1.6	0.008	0.465
GO:0008233	Peptidase activity	51	168	−0.36	−1.51	0.008	0.59

GO, gene ontology; ES, enrichment score; NES, normalized enrichment score; FDR q-val, false discovery rate q value; NOM p-val, nominal p value.