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. 2016 Aug 3;7(9):624–637. doi: 10.1007/s13238-016-0300-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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The HMF promotes the proliferation of NPCs/NSCs from the adult mouse brain. SVZ and hippocampal tissues from young (P15) (A and B) and adult (2-month-old) mice (C and D) were collected and cultured in either the HMF or GMF. The number of NSs per 1000 primary cells (left panels) and the NSs size distributions (right panels) were determined. A greater number of large NSs were observed in young and adult SVZ cultures, as well as young and adult hippocampal cultures. The number of NSs was significantly greater than the HMF only in the adult hippocampal cultures, but was found with no changes in other groups. n is the number of animals. Data are shown as mean ± SEM. P values were calculated using a one-way ANOVA for mean comparisons and using a χ² test for NS size distribution comparison. *P < 0.05; ****P < 0.0001; n.s. P ≥ 0.05