Figure 2.

Roles of p38 MAPKs in satellite cell-driven myogenesis. (Top) Satellite cells in adult muscles are in a quiescent state. Upon injury, satellite cells are activated, undergo asymmetric division and generate a self-renewing daughter cell and a committed progenitor or myoblast which enters the cell cycle. Myoblasts proliferate, differentiate and fuse to form myotubes and new myofibers during adult muscle regeneration. Canonical markers for each stage are indicated-(Bottom) Known substrates and regulated processes by p38α/β and p38γ MAPKs during the different stages of myogenesis. Direct substrates are indicated in red. Linked processes are boxed in gray or black.