Table 8.
Grading | TN/TE-PR | TE-NS3/4A inhibitor | TE-NS5A inhibitor | |||
---|---|---|---|---|---|---|
Non-cirrhosis/cirrhosis | Non-cirrhosis/cirrhosis | Non-cirrhosis | Cirrhosis | |||
(A) GT-1 | ||||||
A1 | SOF/LDV for 12 weeks | SOF/LDV for 12 weeks | ||||
(GT-1b) PrOD for 12 weeks |
||||||
(GT-1b) GZR/EBR for 12 weeks |
||||||
A2 | (GT-1b and RAV Check) ASN/DCV for 24 weeks |
|||||
C1 | Wait | RAV check |
Grading | TN | TE-PR | ||
---|---|---|---|---|
Non-cirrhosis | Cirrhosis | Non-cirrhosis | Cirrhosis | |
(B) GT-2 | ||||
A1 | SOF/RBV for 12 weeks | SOF/RBV for 12 weeks | SOF/RBV for 12 weeks | SOF/RBV for 12 weeks |
A1 | SOF/RBV for 16-24 weeks | |||
B1 (for RBV-intolerant) | SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks |
SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks |
SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks |
SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks |
Grading | TN | TE-PR | ||
---|---|---|---|---|
Non-cirrhosis | Cirrhosis | Non-cirrhosis | Cirrhosis | |
(C) GT-3 | ||||
A1 | SOF/RBV for 24 weeks | SOF/RBV for 24 weeks | SOF/RBV for 24 weeks | SOF/RBV for 24 weeks |
A2 | SOF/DCV for 12 weeks | SOF/DCV ± RBV for 24 weeks |
SOF/DCV for 12 weeks | |
B2 | SOF/RBV for 16 weeks | SOF/DCV/RBV for 24 weeks |
Grading | Non-cirrhosis | Cirrhosis |
---|---|---|
(D) GT-4 | ||
A1 | SOF/LDV for 12 weeks SOF/VEL for 12 weeks |
SOF/LDV for 24 weeks |
B1 | PrO/RBV for 12 weeks | PrO/RBV for 24 weeks SOF/VEL for 24 weeks |
B2 | SOF/DCV/RBV for 12 weeks SOF/DCV for 24 weeks |
|
(E) GT-5/GT-6 | ||
A1 | SOF/VEL for 12 weeks | |
B1 | SOF/LDV for 12 weeks | SOF/DCV for 12 or 24 weeks |
B1 | SOF/LDV for 12 weeks | SOF/LDV for 12 or 24 weeks |
B1 | SOF/VEL for 12 weeks |
TN treatment-naïve; TE treatment-experienced; PR peginterferon plus ribavirin; SOF/LDV sofosbuvir/ledipasvir; PrOD paritaprevir/ritonavir/ombitasvir/dasabuvir; GZR/ EBR grazoprevir/elbasvir; ASN/DCV, asunaprevir/daclatasvir; RAV resistant associated variant
Vel,velpatasvir (will soon be available)