Table 8.

Interferon-free treatment for patients infected with HCV various genotypes (GTs)

Grading	TN/TE-PR		TE-NS3/4A inhibitor		TE-NS5A inhibitor
	Non-cirrhosis/cirrhosis		Non-cirrhosis/cirrhosis		Non-cirrhosis	Cirrhosis
(A) GT-1
A1	SOF/LDV for 12 weeks		SOF/LDV for 12 weeks
	(GT-1b) PrOD for 12 weeks
	(GT-1b) GZR/EBR for 12 weeks
A2	(GT-1b and RAV Check) ASN/DCV for 24 weeks
C1					Wait	RAV check

Grading	TN		TE-PR
	Non-cirrhosis	Cirrhosis	Non-cirrhosis	Cirrhosis
(B) GT-2
A1	SOF/RBV for 12 weeks	SOF/RBV for 12 weeks	SOF/RBV for 12 weeks	SOF/RBV for 12 weeks
A1				SOF/RBV for 16-24 weeks
B1 (for RBV-intolerant)	SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks	SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks	SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks	SOF/DCV for 24 weeks SOF/LDV for 12 weeks SOF/VEL for 12 weeks

Grading	TN		TE-PR
	Non-cirrhosis	Cirrhosis	Non-cirrhosis	Cirrhosis
(C) GT-3
A1	SOF/RBV for 24 weeks	SOF/RBV for 24 weeks	SOF/RBV for 24 weeks	SOF/RBV for 24 weeks
A2	SOF/DCV for 12 weeks	SOF/DCV ± RBV for 24 weeks	SOF/DCV for 12 weeks
B2		SOF/RBV for 16 weeks		SOF/DCV/RBV for 24 weeks

Grading	Non-cirrhosis	Cirrhosis
(D) GT-4
A1	SOF/LDV for 12 weeks SOF/VEL for 12 weeks	SOF/LDV for 24 weeks
B1	PrO/RBV for 12 weeks	PrO/RBV for 24 weeks SOF/VEL for 24 weeks
B2		SOF/DCV/RBV for 12 weeks SOF/DCV for 24 weeks
(E) GT-5/GT-6
A1	SOF/VEL for 12 weeks
B1	SOF/LDV for 12 weeks	SOF/DCV for 12 or 24 weeks
B1	SOF/LDV for 12 weeks	SOF/LDV for 12 or 24 weeks
B1		SOF/VEL for 12 weeks

TN treatment-naïve; TE treatment-experienced; PR peginterferon plus ribavirin; SOF/LDV sofosbuvir/ledipasvir; PrOD paritaprevir/ritonavir/ombitasvir/dasabuvir; GZR/ EBR grazoprevir/elbasvir; ASN/DCV, asunaprevir/daclatasvir; RAV resistant associated variant

Vel,velpatasvir (will soon be available)