Figure 6.

Strain induces CPC alignment. CPCs were seeded on each matrix for 6 hours and then cyclic strain was applied for 24 hours. (a) Quantification of strain-induced matrix-dependent alignment. Kruskal-Wallis one-way ANOVA with Dunn's multiple comparison tests; bars represent mean + SEM; ^∗ p < 0.05 and ^∗∗ p < 0.01; n = 4–7; PLL (brown): poly-L-lysine, LN (green): laminin, FN (purple): fibronectin, COL (blue): collagen I, and cECM (red): naturally derived cardiac extracellular matrix. (b) Representative cell strain images. Blue: DAPI and green: FITC-maleimide; arrow indicates principle direction of strain; 0–15: strain magnitude (%).