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OX1R blockade in the mPFC significantly reduced alcohol drinking. (A) Locations of cannulae shown by gray circles; sections at approximately AP +1.98, +1.78, and +1.70 mm relative to Bregma. (B) Infusion of 3-μg SB within the mPFC decreased alcohol intake. (C,D) No changes in (C) alcohol preference or (D) concurrent water intake. *p < 0.05.
