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OX1R blockade within the medial NAc Shell significantly reduced operant alcohol drinking in rats. (A) Locations of cannulae shown by gray circles; sections at approximately AP +1.70, +1.60, and +1.20 relative to Bregma. (B) Infusion of 3-μg SB within the mNAsh of rats decreased active lever presses for alcohol. (C) No changes in inactive lever presses with SB. (D,E) OX1R inhibition in the mNAsh reduced (D) rewards received and (E) alcohol intake levels. *p < 0.05.
