Table 1.
Microarray data analysis showing genes related to bone development and osteoblast differentiation upregulated in CL1 versus CL2 cells.
| Probe ID | Genbank accession | Gene name | Gene symbol | FC |
|---|---|---|---|---|
| A_23_P167367 | NM_153426 | Paired-like homeodomain 2 | PITX2 | 308.84 |
| A_23_P13907 | NM_000618 | Insulin-like growth factor 1 (somatomedin C) | IGF1 | 118.00 |
| A_23_P55749 | NM_015719 | Collagen, type V, alpha 3 | COL5A3 | 75.11 |
| A_23_P94397 | NM_005014 | Osteomodulin | OMD | 56.07 |
| A_24_P128442 | NM_152380 | T-box 15 | TBX15 | 54.38 |
| A_33_P3708413 | NM_003480 | Microfibrillar associated protein 5 | MFAP5 | 53.73 |
| A_24_P72064 | NM_000163 | Growth hormone receptor | GHR | 51.47 |
| A_23_P215454 | NM_001278939 | Elastin | ELN | 50.15 |
| A_24_P200854 | NM_006735 | Homeobox A2 | HOXA2 | 44.99 |
| A_23_P19624 | NM_001718 | Bone morphogenetic protein 6 | BMP6 | 41.43 |
| A_23_P500501 | NM_000142 | Fibroblast growth factor receptor 3 | FGFR3 | 33.95 |
| A_23_P154605 | NM_018837 | Sulfatase 2 | SULF2 | 29.57 |
| A_23_P28815 | NM_000782 | Cytochrome P450, family 24, subfamily A, polypeptide 1 | CYP24A1 | 22.47 |
| A_23_P210109 | NM_019885 | Cytochrome P450, family 26, subfamily B, polypeptide 1 | CYP26B1 | 22.42 |
| A_23_P323180 | NM_006898 | Homeobox D3 | HOXD3 | 21.08 |
| A_32_P405759 | NM_152888 | Collagen, type XXII, alpha 1 | COL22A1 | 20.36 |
| A_33_P3363799 | NM_001242607 | Neural cell adhesion molecule 1 | NCAM1 | 17.33 |
| A_33_P3381378 | NM_001257096 | Paired box 1 | PAX1 | 17.12 |
| A_23_P383009 | NM_000599 | Insulin-like growth factor binding protein 5 | IGFBP5 | 14.67 |
| A_33_P3382856 | NM_133507 | Decorin | DCN | 14.38 |
| A_23_P10206 | NM_005328 | Hyaluronan synthase 2 | HAS2 | 14.33 |
| A_24_P77904 | NM_018951 | Homeobox A10 | HOXA10 | 13.64 |
| A_23_P2814 | NM_005905 | SMAD family member 9 | SMAD9 | 12.45 |
| A_23_P88404 | NM_003239 | Transforming growth factor, beta 3 | TGFB3 | 12.11 |
| A_32_P4595 | NM_000337 | Sarcoglycan, delta (35 kDa dystrophin-associated glycoprotein) | SGCD | 8.95 |
| A_23_P162171 | NM_006500 | Melanoma cell adhesion molecule | MCAM | 8.60 |
| A_24_P38276 | NM_003505 | Frizzled class receptor 1 | FZD1 | 7.81 |
| A_23_P24129 | NM_012242 | Dickkopf WNT signaling pathway inhibitor 1 | DKK1 | 7.04 |
| A_33_P3264528 | NM_005523 | Homeobox A11 | HOXA11 | 6.64 |
| A_33_P3220470 | NM_005585 | SMAD family member 6 | SMAD6 | 6.47 |
| A_23_P23783 | NM_000261 | Myocilin, trabecular meshwork inducible glucocorticoid response | MYOC | 6.41 |
| A_33_P3263432 | NM_003637 | Integrin, alpha 10 | ITGA10 | 6.35 |
| A_23_P383009 | NM_000599 | Insulin-like growth factor binding protein 5 | IGFBP5 | 6.18 |
| A_33_P3219090 | NM_005542 | Insulin induced gene 1 | INSIG1 | 5.78 |
| A_23_P162589 | NM_001017535 | Vitamin D (1,25-dihydroxyvitamin D3) receptor | VDR | 5.68 |
| A_23_P374695 | NM_000459 | TEK tyrosine kinase, endothelial | TEK | 5.65 |
| A_24_P261169 | NM_006378 | Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM), and short cytoplasmic domain, (semaphorin) 4D | SEMA4D | 5.41 |
| A_33_P3297930 | NM_005202 | Collagen, type VIII, alpha 2 | COL8A2 | 5.138 |
| A_23_P206359 | NM_004360 | Cadherin 1, type 1, E-cadherin (epithelial) | CDH1 | 5.12 |
| A_24_P264943 | NM_000095 | Cartilage oligomeric matrix protein | COMP | 5.07 |
| A_33_P3214948 | NM_014767 | Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan (testican) 2 | SPOCK2 | 4.54 |
| A_24_P55496 | NM_053001 | Odd-skipped related transcription factor 2 | OSR2 | 4.38 |
| A_24_P354689 | NM_004598 | Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan (testican) 1 | SPOCK1 | 4.23 |
| A_23_P69030 | NM_001850 | Collagen, type VIII, alpha 1 | COL8A1 | 3.93 |
| A_23_P128084 | NM_002206 | Integrin, alpha 7 | ITGA7 | 3.91 |
| A_24_P3249 | NM_000965 | Retinoic acid receptor, beta | RARB | 3.91 |
| A_24_P168574 | AJ224867 | GNAS complex locus | GNAS | 3.83 |
| A_23_P320739 | NM_002397 | Myocyte enhancer factor 2C | MEF2C | 3.74 |
| A_23_P429383 | NM_014213 | Homeobox D9 | HOXD9 | 3.54 |
| A_23_P42322 | NM_080680 | Collagen, type XI, alpha 2 | COL11A2 | 3.42 |
| A_23_P160318 | NM_001856 | Collagen, type XVI, alpha 1 | COL16A1 | 3.36 |
| A_33_P3407013 | NM_000600 | Interleukin 6 | IL6 | 3.30 |
| A_23_P315364 | NM_002089 | Chemokine (C-X-C motif) ligand 2 | CXCL2 | 3.29 |
| A_33_P3413168 | BC007696 | Collagen, type XXVII, alpha 1 | COL27A1 | 3.08 |
| A_23_P43164 | NM_015170 | Sulfatase 1 | SULF1 | 3.05 |
| A_23_P58676 | NM_001204375 | Natriuretic peptide receptor 3 | NPR3 | 3.04 |
| A_33_P3290562 | NM_000168 | GLI family zinc finger 3 | GLI3 | 3.00 |
| A_23_P69497 | NM_003278 | C-type lectin domain family 3, member B | CLEC3B | 2.99 |
| A_24_P353619 | NM_000478 | Alkaline phosphatase, liver/bone/kidney | ALPL | 2.99 |
| A_33_P3305749 | NM_000965 | Retinoic acid receptor, beta | RARB | 2.89 |
| A_23_P307328 | NM_007331 | Wolf-Hirschhorn syndrome candidate 1 | WHSC1 | 2.77 |
| A_23_P152305 | NM_001797 | Cadherin 11, type 2, OB-cadherin (osteoblast) | CDH11 | 2.77 |
| A_23_P216361 | NM_021110 | Collagen, type XIV, alpha 1 | COL14A1 | 2.62 |
| A_23_P7313 | NM_001040058 | Secreted phosphoprotein 1 | SPP1 | 2.60 |
| A_24_P267592 | NM_015474 | SAM domain and HD domain 1 | SAMHD1 | 2.54 |
| A_23_P210482 | NM_000022 | Adenosine deaminase | ADA | 2.52 |
| A_23_P148047 | NM_000958 | Prostaglandin E receptor 4 (subtype EP4) | PTGER4 | 2.51 |
| A_23_P345725 | NM_014621 | Homeobox D4 | HOXD4 | 2.47 |
| A_24_P125283 | NM_001015053 | Histone deacetylase 5 | HDAC5 | 2.37 |
| A_33_P3231953 | NM_004370 | Collagen, type XII, alpha 1 | COL12A1 | 2.34 |
| A_24_P298027 | NM_004655 | Axin 2 | AXIN2 | 2.31 |
| A_24_P336551 | NM_199173 | Bone gamma-carboxyglutamate (gla) protein | BGLAP | 2.29 |
| A_33_P3313825 | XM_006713316 | Transforming growth factor, beta receptor II (70/80 kDa) | TGFBR2 | 2.23 |
| A_23_P82990 | NM_033014 | Osteoglycin | OGN | 2.20 |
| A_32_P24585 | NM_001017995 | SH3 and PX domains 2B | SH3PXD2B | 2.20 |
| A_24_P944458 | NM_016133 | Insulin induced gene 2 | INSIG2 | 2.14 |
| A_23_P99063 | NM_002345 | Lumican | LUM | 2.12 |
| A_32_P5251 | NM_001024809 | Retinoic acid receptor, alpha | RARA | 2.11 |
| A_24_P935491 | NM_000090 | Collagen, type III, alpha 1 | COL3A1 | 2.10 |
| A_33_P3312104 | NM_025099 | CTS telomere maintenance complex component 1 | CTC1 | 2.06 |
| A_33_P3321342 | NM_016133 | Insulin induced gene 2 | INSIG2 | 2.04 |
| A_23_P100486 | NM_206824 | Vitamin K epoxide reductase complex, subunit 1 | VKORC1 | 2.02 |
| A_23_P53588 | NM_030775 | Wingless-type MMTV integration site family, member 5B | WNT5B | 2.00 |
| A_23_P616356 | NM_001291902 | Low density lipoprotein receptor-related protein 5 | LRP5 | 2.00 |