Table 3.

Univariate analysis for disease-free survival (DFS) and overall survival (OS)

Variable	DFS			OS
	HR	95% CI	P value	HR	95% CI	P value
Age, years
< 65	-----			-----
≥ 65	1.333	0.869-2.045	0.188	1.354	0.883-2.077	0.165
Gender
Male	-----			-----
Female	0.826	0.552-1.235	0.352	0.829	0.555-1.240	0.362
Location
Right	1.022	0.598-1.748	0.936	1.054	0.617-1.803	0.846
Transverse	1.192	0.528-2.691	0.672	1.201	0.532-2.711	0.659
Left	1.301	0.576-2.938	0.527	1.402	0.620-3.170	0.417
Sigmoid colon	1.053	0.632-1.754	0.844	1.082	0.649-1.802	0.764
Rectum	-----			-----
T stage
T1	0.086	0.120-0.625	0.015*	0.093	0.013-0.675
T2	0.363	0.200-0.660	0.001*	0.370	0.204-0.672	0.001*
T3	0.460	0.296-0.715	0.001*	0.485	0.312-0.754	0.001*
T4	-----			-----
N stage
N0	0.176	0.090-0.346	< 0.001*	0.190	0.097-0.372	< 0.001*
N1	0.346	0.166-0.721	0.005*	0.355	0.171-0.738	0.006*
N2	-----			-----
M stage
M0	-----			-----
M1	3.891	2.119-7.145	< 0.001*	3.536	1.928-6.485	< 0.001*
AJCC stage
I	0.126	0.058-0.278	< 0.001*	0.142	0.065-0.311	< 0.001*
II	0.226	0.119-0.432	< 0.001*	0.259	0.136-0.493	< 0.001*
III	0.406	0.207-0.798	0.009*	0.441	0.225-0.866	0.017*
IV	-----			-----
Differentiation
High	0.889	0.469-1.687	0.719	0.930	0.490-1.766	0.825
Moderate	0.922	0.522-1.631	0.781	0.966	0.546-1.709	0.906
Low	-----			-----
SERPINA4
Negative	11.727	3.691-37.257	< 0.001*	12.268	3.858-39.007	< 0.001*
Weak	3.117	0.913-10.650	0.050*	3.219	0.941-11.010	0.042*
Positive	-----			-----

HR hazard ratio, CI confidence interval.

^* P < 0.05 indicates that the 95% CI of the HR did not include 1.