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. 2016 Aug 1;6(8):1661–1680.

Figure 4.

Figure 4

Microarray analysis revealed the induction of ER stress/UPR by EZH2 inhibitors. A. HCT116 cells were treated with 5 μM UNC1999 or and then microarray analysis was performed. UNC1999/GSK343-regulated genes were analyzed by GSEA. The enrichment plots of “HALLMARK_UNFOLDED_PROTEIN_RESPONSE” and “HALLMARK_CHOLESTEROL_HOMEOSTASIS” were shown. B. The alterations of genes associated with UPR in UNC1999-treated HCT116 cells were analyzed and visualized by IPA. The red and green colors indicate the upregulation and downregulation by UNC1999, respectively.