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Inhibition of ER stress enhanced UNC1999-induced cell death. (A and B) HCT116 cells were treated with indicated doses of UNC1999 with or without 10 μM GSK2606414 for 48 h. The cell viability was analyzed by an MTT assay (A). The protein expressions were analyzed by Western blots (B). *P < 0.05 indicates significant differences between GSK2606414-treated and control cells. (C) A working model for the action mechanism of EZH2 inhibitors.
