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Akt inhibitor sensitizes miR-122-expressing cells to 5-FU-induced apoptosis. (A) Akt phosphorylation and mTORphosphorylation were downregulated by GSK690693 in miR-122-expressing cells as examined by western blot analysis. HepG2 and SNU-449 cells were treated with GSK690693 together with 5-FU. MTT assays (B) and DNA fragmentation assays (C) were performed, which showed that GSK690693 re-sensitized miR-122-expressing cells to 5-FU treatment. The data are presented as the mean ± S.D.
