Table 2.
Plasma membrane proteins displaying 1.3-fold or higher fold-change in differential expression between normal and IBC cells
| Gene | Protein name | UniProtKB accession number | SILAC Ratio |
|---|---|---|---|
| IFITM3 | Interferon induced transmembrane protein 3 | Q01628 | 3.6 |
| TMEM205 | Transmembrane protein 205 | Q6UW68 | 3.5 |
| PLGRKT | Plasminogen receptor (KT) | Q9HBL7 | 3.3 |
| SLC38A10 | Solute Carrier Family 38, Member 10 | Q9HBR0 | 3.3 |
| PDIA6 | Protein disulfide-isomerase A6 | Q15084 | 3.1 |
| C1QBP | Complement component 1Q subcomponent binding protein | Q07021 | 2.9 |
| SIGMAR1 | Sigma Non-Opioid Intracellular Receptor 1 | Q99720 | 2.8 |
| GBAS | Protein NipSnap homolog 2 | O75323 | 2.5 |
| TMEM258 | Transmembrane protein 258 | P61165 | 2.4 |
| ITGB5 | Integrin, beta 5 | P18084 | 2.3 |
| ATAD1 | ATPase family AAA domain-containing protein 1 | Q8NBU5 | 2.2 |
| MCAM | Cell surface glycoprotein MUC18 | P43121 | 2.2 |
| PHB | Prohibitin | P35232 | 2.2 |
| TMEM33 | Transmembrane protein 33 | P57088 | 2.2 |
| ATP6V1A | V-type proton atpase catalytic subunit A | P38606 | 2.1 |
| ENO1 | Enolase 1, (alpha) | P06733 | 2.1 |
| HLA-A | HLA class I histocompatibility antigen, A-33 alpha chain | P16190 | 2.1 |
| HLA-A | HLA class I histocompatibility antigen, A-31 alpha chain | P16189 | 2.1 |
| HLA-E | HLA class I histocompatibility antigen, alpha chain E | P13747 | 2.1 |
| SYPL1 | Synaptophysin-like 1 | Q16563 | 2.0 |
| HLA-A | HLA class I histocompatibility antigen, A-29 alpha chain | P30512 | 1.9 |
| SLC16A3 | Monocarboxylate transporter 4 | O15427 | 1.9 |
| ATP5A1 | ATP synthase subunit alpha, mitochondrial | P25705 | 1.8 |
| ATP5B | ATP synthase subunit beta, mitochondrial | P06576 | 1.8 |
| ATP5O | ATP synthase subunit O, mitochondrial | P48047 | 1.8 |
| MSN | Moesin | P26038 | 1.8 |
| ATP6V1G1 | V-type proton atpase subunit G 1 | O75348 | 1.7 |
| FLOT1 | Flotillin 1 | O75955 | 1.7 |
| HLA-A | HLA class I histocompatibility antigen, A-69 alpha chain | P10316 | 1.7 |
| HLA-A | HLA class I histocompatibility antigen, A-2 alpha chain | P01892 | 1.7 |
| L1CAM | Neural cell adhesion molecule L1 | P32004 | 1.7 |
| MTDH | Protein LYRIC | Q86UE4 | 1.7 |
| RAB18 | Ras-related protein Rab-18 | Q9NP72 | 1.7 |
| RAB3D | Ras-related protein Rab-3D | O95716 | 1.7 |
| RAB8A | Ras-related protein Rab-8A | P61006 | 1.7 |
| RAB8B | Ras-related protein Rab-8B | Q92930 | 1.7 |
| VAMP2 | Vesicle-associated membrane protein 2 | P63027 | 1.7 |
| VAMP3 | Vesicle-associated membrane protein 3 | Q15836 | 1.7 |
| APMAP | Adipocyte plasma membrane associated protein | Q9HDC9 | 1.6 |
| MST1R | Macrophage-stimulating protein receptor | Q04912 | 1.6 |
| NOMO1 | Nodal modulator 1 | Q15155 | 1.6 |
| NOMO3 | Nodal modulator 3 | P69849 | 1.6 |
| SCAMP3 | Secretory carrier-associated membrane protein 3 | O14828 | 1.6 |
| CAP1 | Adenylyl cyclase-associated protein 1 | Q01518 | 1.5 |
| HLA-A | HLA class I histocompatibility antigen, A-68 alpha chain | P01891 | 1.5 |
| KTN1 | Kinectin | Q86UP2 | 1.5 |
| PKP2 | Plakophilin-2 | Q99959 | 1.5 |
| ABCC3 | Canalicular multispecific organic anion transporter 2 | O15438 | 1.4 |
| ATP6V0D1 | V-type proton atpase subunit d 1 | P61421 | 1.4 |
| RAB2B | Ras-related protein Rab-2B | Q8WUD1 | 1.4 |
| SLC35E1 | Solute carrier family 35, member E1 | Q96K37 | 1.4 |
| TPBG | Trophoblast glycoprotein | Q13641 | 1.4 |
| ESYT2 | Extended synaptotagmin-2 | A0FGR8 | 1.3 |
| ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 | Q14573 | 1.3 |
| ZDHHC5 | Palmitoyltransferase ZDHHC5 | Q9C0B5 | 1.3 |
Proteins in Bold were selected for validation via IHC or immunoblotting analysis.