Table 3.
Prognostic value of pathological stage, histological subtype and MST1R expression in renal cell carcinomas, following multivariable analysis using Cox-regression model
| Prognostic Factor | Multivariable Analysis | ||
|---|---|---|---|
|
| |||
| Hazard Ratio (HR) | 95% CI for HR | Cox regression p value | |
| Disease Specific Survivala | |||
| - Stage III/Stage IV (vs Stage I/Stage II) | 38 | 5.4-269 | < 0.001 |
| - pRCC (vs ccRCC) | 22 | 3.1-157 | 0.002 |
| - High MST1Rtotal expression level (vs low MST1Rtotal expression level) | 10 | 1-96 | 0.046 |
| - Stage III/Stage IV (vs Stage I/Stage II) | 26 | 4.4-153 | < 0.001 |
| - pRCC (vs ccRCC) | 14.6 | 2.2-99 | 0.006 |
| - Low MST1Rlong/MST1Rtotal ratio (vs high MST1Rlong/MST1Rtotal ratio) | 4.9 | 1.2-20 | 0.025 |
| Disease Free Survivalb | |||
| - Stage III/Stage IV (vs Stage I/Stage II) | 14 | 3.5-59 | < 0.001 |
| - Low MST1Rlong/MST1Rtotal ratio (vs high MST1Rlong/MST1Rtotal ratio) | 3.2 | 1.1-9.5 | 0.038 |
Only ccRCC and pRCC were included due to insufficient events in chRCC. CI: Confidence Interval; ccRCC: clear cell renal cell carcinoma; pRCC: papillary renal cell carcinoma.
a
Adjusted for patient age.
b
Adjusted for patient age and histological subtype;
MST1Rtotal expression level did not attained statistical significance in multivariable analysis for disease free survival.