Table 2.
Univariable and multivariable analyses of prognostic parameters for survival in Ren Ji cohort 2 patients with pancreatic ductal adenocarcinoma (PDAC)
| Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
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| Prognostic parameter | HR | 95% CI | P value | HR | 95% CI | P value |
| Expression of CTHRC1 (high vs. low) | 1.712 | 1.158-2.531 | 0.007 | 1.588 | 1.059-2.381 | 0.025 |
| Age (≥ 65 vs. < 65) | 1.601 | 1.140-2.251 | 0.007 | 1.842 | 1.294-2.622 | 0.001 |
| Gender (male vs. female) | 0.823 | 0.584-1.160 | 0.266 | - | - | - |
| TNM stage (III, IV vs. I, II) | 1.725 | 1.114-2.672 | 0.015 | 1.242 | 0.696-2.216 | 0.463 |
| Tumor Size (> 3 cm vs. ≤ 3 cm) | 1.590 | 1.111-2.276 | 0.011 | 1.619 | 1.123-2.334 | 0.010 |
| T classification (T3, 4 vs. T1, 2) | 1.540 | 0.988-2.402 | 0.057 | - | - | - |
| Lymph node metastasis (present vs. absent) | 1.869 | 1.313-2.660 | 0.001 | 1.776 | 1.207-2.613 | 0.004 |
| Distant metastasis (present vs. absent) | 2.029 | 1.091-3.775 | 0.025 | 1.308 | 0.584-2.927 | 0.514 |
| Vascular invasion (present vs. absent) | 1.309 | 0.796-2.151 | 0.289 | - | - | - |
| Perineural invasion (present vs. absent) | 1.090 | 0.779-1.525 | 0.614 | - | - | - |
| Tumor location (head vs. body/tail) | 1.065 | 0.746-1.522 | 0.728 | - | - | - |
| Histology (poor vs. well/moderate) | 1.794 | 1.269-2.536 | 0.001 | 1.729 | 1.216-2.459 | 0.012 |
HR: Hazard ratio; CI: Confidence interval. The bold number represents the P-values with significant differences.