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. 2016 Aug 30;6:32207. doi: 10.1038/srep32207

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Copyright © 2016, The Author(s)

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(a) Unsupervised hierarchical clustering based on the ranking of the average methylation levels of 6-mers (NN^mCWNN). Colours indicate cell types. Distance is defined as (1−ρ²), where ρ is Spearman’s correlation coefficient, measuring the similarity of the sequence preferences based on the bulk methylation levels of 6-mers for each sample pair. Clustering method, complete. (b) Logo plots of the normalized mCW motifs.