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. 2016 Aug 30;6:32207. doi: 10.1038/srep32207

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Profiles of brain mCW across LINE-1 elements in humans (a) and mice (b). Examples of mCW profiles across subtypes of LINE-1 elements, including L1PA (youngest), L1PB, L1MA, L1MB, L1MC, L1MD, and L1ME (most ancient) in humans (c) and L1Md_T (youngest), L1_Mus, L1_Mur, L1MA, L1MB, L1MC, L1MD, and L1ME (most ancient) in mice (d), showing that young LINE-1 elements prefer lower mCW. Profiles of PGC mCG across LINE-1 elements in humans (e) and mice (f). Examples of mCG profiles across subtypes of LINE-1, from young to ancient in humans (g) and mice (h), showing that young LINE-1 elements prefer higher mCG at promoters.