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. 2016 Aug 30;6:32207. doi: 10.1038/srep32207

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Profiles of mCW across the sub-groups of human Alu elements from 500 bp upstream to 500 bp downstream in brain neuron, ES and oocyte. The mCW levels are shown for the sense strand (red) and antisense strand (green) separately. AluJo is the most ancient, and AluY is the youngest Alu elements. Yellow blocks mark the loci of Alu elements, where mCW levels increase with the evolution of Alu elements. The corresponding sequence mutations are shown below the profiles, and the nucleotides at the mutated positions are marked in red.