Table 2. Estimated ABCG2 function and SUA of hemodialysis patients and acute gastroenteritis patients.
| Estimated ABCG2 function (Diplotype of Q126X and Q141K)* | Hemodialysis |
Acute gastroenteritis |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case |
Control† |
Acute period |
Recovery period |
|||||||||
| N | SUA (mg/dl) | β (SEM)‡ P value§ | N | SUA (mg/dl) | β (SEM)‡ P value§ | N | SUA (mg/dl) | β (SEM)‡ P value|| | N | SUA (mg/dl) | β (SEM)‡ P value|| | |
| Full function (*1/*1) | 51 | 7.1 ± 0.1 | 50 | 5.3 ± 0.2 | 29 | 7.5 ± 0.5 | 24 | 4.2 ± 0.3 | ||||
| 3/4 function (*1/*2) | 46 | 7.9 ± 0.1 | 41 | 5.0 ± 0.2 | 30 | 9.6 ± 0.7 | 24 | 4.9 ± 0.4 | ||||
| ≤1/2 function (*1/*3, *2/*2, *2/*3 or *3/*3) | 9 | 8.4 ± 0.7 | 15 | 6.0 ± 0.3 | 8 | 10.6 ± 1.4 | 7 | 5.4 ± 0.6 | ||||
| Total | 106 | 7.5 ± 0.1 | 0.63 (0.16) P = 1.1 × 10−4 | 106 | 5.3 ± 0.1 | 0.17 (0.18) P = 0.36 | 67 | 8.8 ± 0.4 | 1.73 (0.61) P = 6.3 × 10−3 | 55 | 4.7 ± 0.2 | 0.60 (0.36) P = 0.10 |
N, number; SUA, serum uric acid.
Plus-minus values are means ± SEM.
**1, *2 and *3 represent haplotypes of two dysfunctional variants (Q126X and Q141K) as previously reported. Detailed information on ABCG2 haplotypes is also shown in Table 1.
†106 controls were matched for sex- and body-mass index to 106 hemodialysis patients and selected from health examination participants in J-MICC Study.
‡β means regression coefficient.
§P values were obtained by multiple regression analysis including ABCG2 function and age in the model.
||P values were obtained by linear regression analysis.