Figure 3. Fabrication, characterization and degradation of cryoGelMA NGCs used for nerve repair in rat sciatic nerve transection model.
(A) The diameters of the transected sciatic nerve were measured for NGCs design and fabrication. (B) SEM micrographs of the NGCs. (C) Degradation of the NGCs in presence of collagenase type II (1 mg/ml) solution in vitro (n = 3). (D) Photographs of the biodegradable NGCs subcutaneously on the dorsal site of rats at 1, 2, 4, and 8 weeks after implantation (scale bars = 5 mm). (E) Representative H&E staining of tissue sections of the NGCs at various time point (1, 2, 4, and 8 weeks) after implantation (scale bars = 200 μm).