Table 3. Drug doses and blood levels.
| Control | BKV | P value | |
|---|---|---|---|
| Tac mean trough level (ng/ml) | |||
| after 1 month (n = 75/71) | 11.1 ± 3.8 | 9.9 ± 3.6 | 0.017a |
| after 3 months (n = 70/67) | 9.6 ± 3.0 | 8.7 ± 2.6 | 0.149a |
| after 6 months (n = 67/62) | 8.3 ± 2.7 | 7.2 ± 2.1 | 0.012a |
| at BKV pos (n = 66) | − | 8.9 ± 3.4 | − |
| Tac mean daily dose (mg) | |||
| after 1 month (n = 74/71) | 9.0 (3–22) | 11.0 (2–20) | 0.064b |
| after 3 months (n = 69/67) | 6 (1.5–22) | 7 (2–20) | 0.135b |
| after 6 months (n = 66/62) | 4.5 (0.5–21) | 5 (2–20) | 0.082b |
| at BKV pos (n = 42) | − | 7 (2–16) | − |
| Tac C/D ratio | |||
| after 1 month (n = 74/71) | 1.15 (0.28–5.05) | 0.85 (0.30–8.75) | 0.002b |
| after 3 months (n = 67/67) | 1.58 (0.35–9.93) | 1.16 (0.31–5.35) | 0.017b |
| after 6 months (n = 66/62) | 1.76 (0.43–7.20) | 1.30 (0.44–4.20) | 0.001b |
| at BKV pos (n = 37) | − | 1.34 (0.33–3.95) | − |
| log Tac C/D ratio | |||
| after 1 month (n = 74/71) | 0.14 (−1.27–1.62) | −0.17 (−1.20–2.17) | 0.002b |
| after 3 months (n = 69/67) | 0.45 (−1.04–2.30) | 0.15 (−1.18–1.68) | 0.017b |
| after 6 months (n = 66/62) | 0.56 (−0.85–1.97) | 0.26 (−0.83–1.44) | 0.001b |
| at BKV pos (n = 37) | 0.29 (−1.11–1.37) | − | |
| Tac metabolism groups | |||
| after 1 month slow metab. (n = 69) | 45 (61%) | 24 (34%) | 0.002c |
| fast metab. (n = 76) | 29 (39%) | 47 (66%) | |
| after 3 months slow metab. (n = 90) | 51 (74%) | 39 (58%) | 0.070c |
| fast metab. (n = 46) | 18 (26%) | 28 (42%) | |
| after 6 months slow metab. (n = 93) | 53 (80%) | 40 (65%) | 0.050c |
| fast metab. (n = 35) | 13 (20%) | 22 (35%) | |
| prednisolone daily dose (mg) | |||
| after 1 month (n = 82/85) | 20 (5–30) | 20 (7.5–30) | 0.089b |
| after 3 months (n = 81/85) | 10 (5–20) | 10 (5–50) | 0.018b |
| after 6 months (n = 82/85) | 5 (2.5–20) | 5 (2.5–40) | 0.058b |
| at BKV pos (n = 50) | − | 10 (2.5–50) | − |
For Tac dose and trough level calculation, only Tac twice daily was included. Results are reported as absolute and relative frequencies, mean ± standard deviation or median (minimum-maximum).
Abbreviations: BKV, BK virus; Tac, tacrolimus; C/D ratio, concentration/dose ratio; IS, immunosuppression.
at test for independent groups.
bMann Whitney U test.
cFisher’s exact test; fast metabolism was defined as Tac C/D ratio <1.05, slow mebabolism was defined as Tac C/D ratio ≥1.05.