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. 2016 Aug 30;6:32232. doi: 10.1038/srep32232

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Copyright © 2016, The Author(s)

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(A) Pathways that were significantly affected by the up-regulated miRNA targets included transcriptional misregulation in cancer, PI3K-Akt signaling pathway and cell adhesion (left panel). The pathways that were significantly affected by the down-regulated miRNA targets included neurotrophin signaling pathway, lysosome, gastric acid secretion and calcium signaling pathway (right panel). (B) The GO terms that were significantly affected by the up-regulated miRNA targets included regulation of transcription, cell fate commitment, regulation of Ras GTPase and others (left panel). The GO terms that were significantly affected by the down-regulated miRNA targets included signal transduction, apoptotic process, regulation of transcription and others (right panel). Black Box represented that the FDR value of pathway or GO is less than 0.05.