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. 2016 Jul 21;4(3):300–314. doi: 10.1002/iid3.114

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© 2016 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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M (IFNγ + LPS) macrophages have high expression levels of inflammation/fibrosis‐related ECM molecules. PCR array to determine the expression of ECM‐related genes. A: Venn diagram showing gene expression changes identified by comparing the three different macrophage subpopulations. B: Common and unique genes identified in the comparisons in A. C–E: Network analysis of proteolytic pathways related to each macrophage phenotype. The purple lines represent enzyme‐substrate interactions, and the orange lines represent physical interactions. C: Comparisons between M0 and M (IFNγ + LPS) or M (IL4 + IL13) macrophages. The red boxes represent up‐regulated genes, and the green boxes depict down‐regulated genes in M0. D: Comparison between M (IFNγ + LPS) and M0 macrophages. The red boxes represent up‐regulated genes, and the green boxes depict down‐regulated genes in M (IFNγ + LPS). E: Comparison between M (IL4 + IL13) and M0 macrophages. The red boxes represent up‐regulated genes, and the green boxes depict down‐regulated genes in M (IL4 + IL13). All array data are presented as the average gene expression level of ten combined mice per group.