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. Author manuscript; available in PMC: 2017 Aug 24.
Published in final edited form as: J Am Chem Soc. 2016 Aug 9;138(33):10561–10570. doi: 10.1021/jacs.6b05484

Table 3.

Impact of exogenous DNA on cytotoxicity of natural products.a

IC50 (nM) in presence of added DNAb
compound 0 µg 4 µg 12 µg 40 µg
actinomycin 0.5 1.5 5.9 51
paclitaxel 6.4 7.8 7.2 6.4
kibdelone C 67 43 64 61
a

Herring sperm DNA was added to H2122 cell cultures at the indicated levels in 96-well plates, and cells were incubated for 4 days prior to quantifying cell viability with CellTiter-Glo®.

b

Calculated concentrations at which there were 50% fewer viable cells compared to DMSO control.