Skip to main content
letter
. 2016 May;101(5):e177–e181. doi: 10.3324/haematol.2015.129015

Figure 1.

Figure 1.

Alterations of Ery-Is in myelodysplastic syndromes (MDS) compared to healthy bone marrow (BM) and their prognostic relevance. In MDS, the numerical density of Ery-Is within marrow was significantly lower than in healthy BM (A–C) whereas Ery-Is were enlarged (D–F; P<0.000001). These differences were independent of patient sex (A, B, D, E; P>0.05). In healthy marrow, numerical density and size of Ery-Is changed significantly with age (C, F; P<0.001; blue lines) whereas the alterations observed in MDS were independent of age (C, F; P>0.05; red lines). In healthy marrow as well as in MDS, the size of Ery-Is (mean diameter) correlated inversely with their numerical density within marrow (P<0.000001). The risk of transfusion-dependent anemia and acute myeloid leukemia (AML)-free survival time significantly depended on the numerical density of Ery-Is within BM (G, H; P<0.00002).