Figure 1.

Multi-state model. The name of each state reflects the event the occurrence of which makes the patient enter the state; he/she remains in this state until a next event occurs or until the end of follow-up. Patients entered a new state on the day when such an event took place and could not visit the same state twice. The starting state of all patients is 1. SCT. The intermediate states are depicted by numbers 2 to 6. Each arrow indicates a possible transition to an intermediate state in the model. Transition between severe GvHD (Start IS) and initiation of DLI was only possible after cessation of systemic immunosuppression. The absorbing states (in red) are Relapse and NRM. States 1, 3, 4, 6 (in green) indicate treatment success; states 2, 5, 7, 8 (in orange and red) indicate treatment failure. Transition to the absorbing states was possible from any other state in the model; for simplicity these transitions are omitted from the figure.