Figure 6.

Signaling and not protease inhibitory function of TIMP-1 impacts on neutrophil homeostasis. (A) Adenovirus coding for different TIMP-1 variants was i.v. injected into DBA/2 mice, and peripheral blood neutrophils were quantified by flow cytometry three days after transduction. (B) Relative quantification of neutrophil precursors in BM of mice from (A) by flow cytometry. (C) Expression of neutrophil maturation markers and transcription factors in BM as analyzed by qRT-PCR. Columns: mean; Bars: SEM; Student’s t-test. ns: not significant; *P<0.05; **P<0.01; ***P<0.001, n=5.