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. 2015 Aug;100(8):1014–1022. doi: 10.3324/haematol.2014.115410

Figure 2.

Figure 2.

Chronic IFNα expression affects the composition of bone marrow differentiated cell population. Three weeks after vector injection (5–6 mice/group) the composition of BM cells from AAV-IFNα-treated mice was compared with the AAV-luc-treated mice. (A) (left) The mean numbers of CD19+ cells (B cells) per femur are represented. (right) Representative flow cytometry histogram analysis of the CD19+ cells in BM of AAV-treated mice at the end of the experiment. (B) Mean numbers of CD11b+ (monocytes), NK1.1+ (NK-cells), Ter-119+ (erythrocytes), CD41+ (platelets) per femur. (C) (left) Mean numbers of CD4+, CD8+ (T cells) and double-positive cells per femur. (right) Representative flow cytometry analysis of the CD4+ and/or CD8+ cells in BM obtained from AAV-treated mice at the end of the experiment. (D) (left) Mean percentages of CD8+ T cells per femur in G0-G1, S or G2-M phase. (right) Representative flow cytometry analysis of CD8+ cells cycle in BM AAV-treated mice at the end of the experiment. The inserts report the percentages of cells for each quadrant. Results are expressed as the mean+SD. Statistical significance was determined by Student t-test (*P≤0.05; **P≤0.01; ***P≤0.001).