Figure 2.

BRCC3 mutations and commonly associated other mutations. (A) Serial analysis of variant allelic frequencies (VAF) measured by targeted deep sequencing in a representative patient with a BRCC3 mutation at the diagnosis of RCMD and upon progression to RAEB. Co-existing gene mutation VAF shifts are indicated by corresponding lines. (B) A Circos plot illustrating co-existing mutations in 16 selected genes. (C) Co-existing mutations in the BRCC3-mutated cohort; 27 out of 28 cases were positive for other somatic mutations.