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. 2016 Sep 28;3(6):e281. doi: 10.1212/NXI.0000000000000281

Figure. Model supporting noradrenergic signaling in stiff-person syndrome (SPS) pathophysiology and clinical exacerbations.

Figure.

(A) Proposed model of serotonin and norepinephrine in SPS. (B) Clinical course of serotonin-norepinephrine reuptake inhibitor (SNRI) use in patients. Clinical exacerbations noted with blue arrow. 5-HT = 5-hydroxytryptamine; IVIg = IV immunoglobulin; NE = norepinephrine; PLEX = plasmapheresis; SLS = stiff-limb syndrome; SSRI = selective serotonin reuptake inhibitor; TCA = tricyclic antidepressant.