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. 2016 Aug 25;7:133. doi: 10.3389/fneur.2016.00133

Figure 1.

Figure 1

Effects of noise exposure on the auditory periphery of mice (A,C). ABR thresholds for tone-pip stimulation. Pre-exposure thresholds ±1 SEM are indicated by the shaded areas, thresholds 1 day postexposure by dashed lines, and 4 weeks postexposure by solid lines [(A) – 100 dB SPL exposure, blue; (C) – 105 dB SPL exposure, red]. (B,D) Growth function of the amplitudes of ABR waves I and IV (50 μs clicks) for control (black lines) and noise-exposed mice [(B) – 100 dB SPL exposure in blue; (D) – 105 dB SPL exposure in red]. Pre-exposure data ± 1 SEM are indicated by the shaded areas, 1 day postexposure by dashed and 4 weeks postexposure by solid lines. Both levels of noise exposure caused a significant reduction of ABR wave I amplitude. (E) Examples of inner hair cells from a control mouse (left, scale bar = 5μm) and a mouse exposed to 105 dB SPL noise (right), with synaptic ribbons labeled green (anti-CtBP2) and postsynaptic terminals red (anti-GluR2/3). (F) Mean number of synaptic ribbons per IHC; black, control (n = 6 cochleas); blue, 100 dB SPL exposure (n = 3 cochleas); red, 105 dB SPL (n = 4 cochleas). There was a significant difference in the ribbon count per IHC between control and noise exposed ears for both noise conditions (ANOVA, p = 0.03).