Table 2.

Mitochondrial haplogroups and virologic and immunological HIV outcomes in 91 HAART-naïve African American adolescents of the REACH study

	linear mixed model¶
	setpoint viral load				CD4+ T cell count trajectory
Mitochondrial macrohaplogroup	frequency	coefficient	(SE)	p §	frequency	coefficient	(SE)	p §†
L1*	17	−0.29	(0.19)	0.143	17	0.007	(0.024)	0.815
L2	6	0.15	(0.30)	0.618	6	−0.150	(0.095)	0.121
L2*	22	−0.02	(0.18)	0.925	22	−0.070	(0.024)	0.002
L3	6	−0.34	(0.30)	0.249	6	0.051	(0.075)	0.499
L3*	30	0.11	(0.16)	0.479	30	0.016	(0.021)	0.450
R0	8	0.44	(0.27)	0.105	6	0.015	(0.042)	0.731
U	−	−	−	−	4	0.040	(0.034)	0.429
L2 + L2*	28	0.15	(0.30)	0.618	28	−0.081	(0.023)	0.0005

Footnote to Table 2

^*Macro-haplogroups as defined in the histogram of Figure 1. Note that non-L haplogroups H, HV, V and root R0 were grouped as R0, and the U and K haplogroups as U.

^¶Models adjusted for the effects of gender, baseline age and HLA-B.

^§p-values adjusted for multiple comparisons (Tukey-Kramer adjustment). Note that only clades or macrohaplogroups with a frequency greater than 3% are shown. SE=Standard Error of the mean.

^†Parameter estimates for the covariates in the model with L2 & L2* as predictors were for HLA-B*35 (beta= −1.62; SE=1.81; p= 0.370), HLA-B*57 or HLA-B*27 (beta=3.01; SE=1.44; p=0.037), gender (beta= −1.45; SE=1.30; p =0.265) and for age (beta= 0.066; SE=0.25; p=0.795).