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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Contraception. 2015 Oct 9;93(1):70–76. doi: 10.1016/j.contraception.2015.09.015

Table 2.

Clotting factor values during the first OC cycle

Cycle Day OC10 OC124 OC224 OC324 OC624 OC21a OC28
D-dimer (mcg/mL)
  Geometric mean
  (±95% CI)b 		0.31
(0.22, 0.44)		 0.37
(0.25, 0.55)		 0.42
(0.24, 0.71)		 0.37
(0.26, 0.53)		 0.81
(0.39, 1.71)		 0.72
(0.46, 1.11)		 0.45
(0.27, 0.75)
  p-valuec - 0.47 0.31 0.36 0.013 0.012 0.28
  Correlation coefficientd
  (±95% CI)b,d 		- 0.24
(−0.29, 0.66)		 0.18
(−0.33, 0.63)		 0.36
(−0.15, 0.72)		 0.30
(−0.21, 0.68)		 −0.23
(−0.64, 0.28)		 −0.16
(−0.64, 0.40)
  p-valued 0.38 0.50 0.16 0.25 0.52 0.59
Factor VIII activity (%)
  Geometric mean
  (±95% CI)b 		100
(81, 124)		 109
(85, 141)		 126
(105, 153)		 127
(107, 149)		 117
(94, 146)		 109
(88, 135)		 103
(82, 129)
  p-valuec - 0.36 <0.001 0.011 0.076 0.24 0.92
  Correlation coefficientd
  (±95% CI)b,d 		- 0.66
(0.26, 0.87)		 0.87
(0.67, 0.95)		 0.61
(0.18, 0.84)		 0.66
(0.26, 0.87)		 0.74
(0.40, 0.90)		 0.62
(0.13, 0.87)
  p-valued 0.003 <0.001 0.008 0.003 <0.001 0.016
Protein C total antigen (%)
  Geometric mean
  (±95% CI)b 		100
(93, 107)		 101
(94, 108)		 101
(94, 108)		 101
(94, 108)		 102
(95, 108)		 106
(99, 114)		 105
(98, 113)
  p-valuec - 0.83 0.69 0.66 0.52 0.48 0.22
  Correlation coefficientd
  (±95% CI)b,d 		- 0.57
(0.12, 0.82)		 0.67
(0.28, 0.87)		 0.82
(0.56, 0.93)		 0.70
(0.33, 0.88)		 0.51
(0.04, 0.80)		 0.56
(0.04, 0.84)
  p-valued 0.015 0.002 <0.001 0.001 0.035 0.036
a

OC21, average of values at t=0 and t=24 hrs;

b

CI, confidence interval;

c

Paired t-test against OC10;

d

Correlation with OC10; CI and p-value calculated with Fisher’s z-transformation of correlation coefficient.