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. 2016 Jul 11;5(8):1149–1162. doi: 10.1242/bio.016790

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Increased caloric intake corresponds with progressive weight gain, hyperglycaemia, formation of advanced glycation end products, dyslipidemia and serum inflammatory markers in mice fed an energy-dense (ED) diet for 30 weeks. (A) Daily energy intake and (B) weight gain of mice fed a standard (SD; n=22) and an ED (n=23) diet for 30 weeks. Compared with controls, fasting plasma (C) glucose concentrations and (D) glycosylated haemoglobin (HbA_1c) were significantly higher in ED diet-fed mice throughout the study period. Mice consuming the ED diet also had significantly increased (E) plasma cholesterol and (F) C-reactive protein (CRP) at 10, 20 and 30 weeks when compared with control animals. Data are mean±95% c.i. Significant differences were analysed by two-way ANOVA and Sidak's multiple comparison post tests and indicated as ***P≤0.001.