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. 2016 Feb 2;27(9):2616–2621. doi: 10.1681/ASN.2015040439

Figure 2.

Figure 2.

Isolated PTs from RPTPγ knockout mice do not respond to changes in either [CO2]BL or [HCO3−]BL. (A) Dependence of JHCO3, in WT versus RPTPγ−/− PTs, on BL [CO2], using OOE solutions to vary [CO2]BL at a fixed [HCO3−]BL of 22 mM and a fixed pHBL of 7.40 (37°C). (B) Dependence of JV on [CO2]BL in the same tubules as in panel A. (C) Dependence of JHCO3, in WT versus RPTPγ−/− PTs, on [HCO3−]BL, using OOE solutions to vary [HCO3−]BL at a fixed [CO2]BL of 5% and a fixed pHBL of 7.40. (D) Dependence of JV on [HCO3−]BL in the tubules from panel C.