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Increased urinary excretion of hhep25 and isoforms hhep22 and hhep20 in succinylated gelatin-treated and megalin deficient mice. Urinary concentration per millimolar creatinine of (A) hhep25, (B) hhep22, and (C) hhep20 after 1 and 24 hours in wild-type mice (white bars), mice pretreated with succinylated gelatin (Gelo) (black bars), and megalinf/f,wt mice and megalinf/f,Cre mice (checkered bars; n=4–5 per group). *P<0.05 using t test; **P<0.01 using t test.
