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Filtered hepcidin is reabsorbed in proximal tubules via megalin-mediated endocytosis. Double staining of (A) megalin and hepcidin (indicated by arrows) and (B) megalin and Lotus Tetragonolobus Agglutinin (LTA)-FITC in wild-type and megalinf/f,Cre mice treated with hhep25 for 1hour. D, distal tubule; G, glomeruli. Scalebar, 20 μm. *Megalin-deficient tubules without hepcidin.
