Table 2.

Association of eGFR and urine ACR with hemorrhage when examined as a continuous variable

Cohort and Variable	Unadjusted RR (95% CI)a	Adjusted RR (95% CI)	P Value
Total cohort
eGFR, ml/min per 1.73 m2	0.73 (0.72 to 0.74)	0.91 (0.89 to 0.92)b	<0.001
Urine ACR, mg/g	1.02 (1.01 to 1.02)	1.02 (1.01 to 1.02)c	<0.001
Age ≥66 yr old
eGFR, ml/min per 1.73 m2	0.81 (0.80 to 0.83)	0.91 (0.89 to 0.93)b,d	<0.001
Urine ACR, mg/g	1.02 (1.02 to 1.03)	1.02 (1.01 to 1.02)c,d	<0.001

^aRR reported for a 10-U increase of eGFR or 88.5-U increase of ACR. For ACR, to convert from milligrams per gram to milligrams per millimole, multiply by 0.113.

^bAdjusted for age (per year), sex, income quintile (lowest referent), ischemic stroke, myocardial infarction, coronary artery disease, coronary revascularization, deep venous thrombosis, atrial fibrillation, hypertension, congestive heart failure, diabetes, prior hemorrhage, residential status, year of index date (2002 referent), and urine ACR (continuous).

^cAdjusted for age (per year), sex, income quintile (lowest referent), ischemic stroke, myocardial infarction, coronary artery disease, coronary revascularization, deep venous thrombosis, atrial fibrillation, hypertension, congestive heart failure, diabetes, prior hemorrhage, residential status year of index date (2002 referent), and eGFR (continuous).

^dAnalysis restricted to individuals ages ≥66 years old. Also adjusted for anticoagulant, antiplatelet, and proton pump inhibitor use.