Table 3.
Risk of all–cause major hemorrhage by eGFR and urine ACR
| CKD Stage by eGFR Categories | Albuminuria Categories, mg/g | ||
|---|---|---|---|
| <30 | 30–300 | >300 | |
| ≥90 ml/min per 1.73 m2 | |||
| IR per 1000 person-yr (95% CI) | 1.6 (1.5 to 1.7)a | 3.1 (2.7 to 3.4)b | 4.5 (3.6 to 5.8)c |
| Adjusted RRd (95% CI) | Referent | 1.6 (1.4 to 1.8)b | 2.3 (1.8 to 2.9)c |
| 60 to <90 ml/min per 1.73 m2 | |||
| IR per 1000 person-yr (95% CI) | 3.1 (2.9 to 3.2)a | 6.7 (6.2 to 7.2)b | 10.7 (9.3 to 12.2)c |
| Adjusted RRd (95% CI) | 1.0 (0.9 to 1.1)a | 1.6 (1.4 to 1.8)b | 2.5 (2.2 to 3.0)c |
| 45 to <60 ml/min per 1.73 m2 | |||
| IR per 1000 person-yr (95% CI) | 7.1 (6.6 to 7.7)b | 10.4 (9.4 to 11.6)c | 15.0 (12.7 to 17.6)e |
| Adjusted RRd (95% CI) | 1.4 (1.2 to 1.6)b | 1.7 (1.4 to 1.9)c | 2.6 (2.2 to 3.2)e |
| 30 to <45 ml/min per 1.73 m2 | |||
| IR per 1000 person-yr (95% CI) | 11.4 (10.3 to 12.7)c | 18.2 (16.3 to 20.2)e | 19.3 (16.5 to 22.5)e |
| Adjusted RRd (95% CI) | 1.7 (1.5 to 2.0)c | 2.3 (2.0 to 2.6)e | 2.8 (2.3 to 3.3)e |
| 15 to <30 ml/min per 1.73 m2 | |||
| IR per 1000 person-yr (95% CI) | 17.1 (14.1 to 20.8)e | 21.6 (18.3 to 25.5)e | 29.5 (25.0 to 34.7)e |
| Adjusted RRd (95% CI) | 1.9 (1.5 to 2.4)e | 2.4 (1.9 to 2.9)e | 3.7 (3.0 to 4.5)e |
| <15 ml/min per 1.73 m2 | |||
| IR per 1000 person-yr (95% CI) | 29.3 (13.3 to 64.4)e | 35.1 (22.0 to 56.0)e | 42.4 (30.9 to 58.5)e |
| Adjusted RRd (95% CI) | 3.0 (1.3 to 6.6)e | 3.5 (2.2 to 5.6)e | 5.5 (3.9 to 7.6)e |
Categories of eGFR and ACR on the basis of the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) nomenclature, which classifies adults into four categories by CKD prognosis (low, moderate, high, or very high risk). ACR was determined by a random spot urine albumin-to-creatinine ratio.
KDIGO CKD risk group: low.
KDIGO CKD risk group: moderate.
KDIGO CKD risk group: high.
Adjusted for age (per year), sex, income quintile (lowest referent), ischemic stroke, myocardial infarction, coronary artery disease, coronary revascularization, deep venous thrombosis, atrial fibrillation, hypertension, congestive heart failure, diabetes, prior hemorrhage, residential status and year of index date (2002 referent).
KDIGO CKD risk group: very high.