Table 2.

Significance of sex and genotypes to the eGFR and htTKV phenotypes and ICC analysis: Kidney disease

Variable and Population	eGFRa Difference (P Value)	htTKV Difference, % (P Value)	Figure	ICC eGFR (P Value)	ICC htTKV (P Value)
Sex: Womenb
Total study	+4.34 (0.0002)c	−22.1 (<0.0001)c	Figure 1, A and B	0.12 (0.06)	0.46 (<0.001)c
PKD1	+3.48 (0.009)c	−19.7 (<0.0001)c	Figure 1, C and D	0.13 (0.07)	0.40 (<0.001)c
PKD2	+8.47 (0.002)c	−19.7 (0.07)	Figure 1E, Supplemental Figure 1	0.09 (0.32)	0.63 (0.01)c
Gene
Total study			Figure 2, A and B	0.12 (0.06)	0.46 (<0.001)c
PKD2d	+13.49 (<0.0001)c	−34.3 (<0.0001)c
NMDd	+9.42 (<0.0001)c	−30.9 (<0.0001)c
Mutation position: 3′ halfe
PKD1	−2.18 (0.11)	+7.8 (0.06)	Supplemental Figure 2, A and B	0.13 (0.07)	0.39 (<0.001)c
PKD2	−2.05 (0.45)	−15.2 (0.12)	Supplemental Figure 2, C and D	0.07 (0.34)	0.62 (0.02)c
Mutation type: PKD1			Figure 3, A and B	0.12 (0.09)	0.46 (<0.001)c
Splicef	−1.06 (0.65)	+1.0 (0.94)
Nonsensef	+0.45 (0.46)	−3.9 (0.46)
Missensef	+6.16 (0.0004)c	−10.4 (0.06)
In frame D/If	+5.63 (0.05)	+6.2 (0.46)
Mutation effect: Nontruncatingg
PKD1	+5.09 (0.0003)c	−5.8 (0.16)	Figure 3, C and D	0.13 (0.07)	0.40 (<0.001)c
PKD2	+3.34 (0.34)	−10.4 (0.35)	Supplemental Figure 3	0.09 (0.31)	0.63 (0.01)c
Mutation group: PKD1			Figure 4, A and B	0.14 (0.06)	0.39 (<0.001)c
MSG2h	+2.90 (0.09)	+3.2 (0.71)
MSG3h	+7.80 (<0.0001)c	−17.3 (0.003)c

D/I, deletion or insertion.

^aIn milliliters per minute per 1.73 m² calculated using the CKD-EPI equation.

^bVersus men.

^cSignificant.

^dVersus PKD1.

^eVersus 5′ half.

^fVersus frameshifting.

^gVersus truncating.

^hVersus MSG1.