Table 1.
Recipient characteristics
| Covariate | All Patients, n=13,789 | No RMM, n=9921; 72% | One or More RMM, n=3868; 28% | P Value |
|---|---|---|---|---|
| Age, yr | <0.001 | |||
| 18–39 | 5529 (40) | 4116 (42) | 1413 (37) | |
| 40–49 | 3698 (27) | 2614 (26) | 1084 (28) | |
| 50–59 | 2916 (21) | 2033 (20) | 883 (23) | |
| ≥60 | 1646 (12) | 1158 (12) | 488 (12) | |
| Women | 5572 (40) | 3980 (40) | 1592 (41) | 0.26 |
| Race | <0.001 | |||
| Black | 3631 (26) | 2736 (28) | 895 (23) | |
| Nonblack | 10,158 (74) | 7185 (72) | 2973 (77) | |
| ESRD cause | <0.001 | |||
| DM | 1961 (14) | 1307 (13) | 654 (16) | |
| GN | 5059 (37) | 3642 (37) | 1417 (37) | |
| Other | 6769 (49) | 4972 (50) | 1797 (46) | |
| First transplant characteristics | ||||
| Living donor | 5241 (38) | 3747 (38) | 1494 (39) | 0.35 |
| Deceased donor | 8548 (62) | 6174 (62) | 2374 (61) | |
| Peak PRA % | 0.30 | |||
| 0 | 5216 (49) | 3786 (50) | 1430 (48) | |
| 1–10 | 3311 (31) | 2343 (31) | 968 (33) | |
| 11–30 | 1118 (11) | 805 (10) | 313 (11) | |
| >30 | 947 (9) | 689 (9) | 258 (9) | |
| HLA mismatch | <0.001 | |||
| 1 | 771 (6) | 660 (7) | 111 (3) | |
| 2 | 2404 (18) | 1906 (19) | 498 (13) | |
| 3 | 3995 (29) | 2952 (30) | 1043 (27) | |
| 4 | 3050 (22) | 2128 (22) | 922 (24) | |
| 5 | 2356 (17) | 1513 (15) | 843 (22) | |
| 6 | 1056 (8) | 644 (7) | 412 (11) | |
| CSA | 9611 (70) | 6955 (70) | 2656 (69) | 0.26 |
| TAC | 3182 (23) | 2258 (23) | 924 (24) | |
| Neither CSA nor TAC | 996 (7) | 708 (7) | 288 (7) | |
| Aza | 6784 (49) | 4926 (50) | 1858 (48) | 0.23 |
| MMF | 4828 (35) | 3,445 (35) | 1383 (36) | |
| Neither Aza nor MMF | 2177 (16) | 1550 (16) | 627 (16) | |
| Induction | 0.43 | |||
| Depleting Ab | 5543 (40) | 3946 (40) | 1597 (41) | |
| Nondepleting Ab | 1301 (10) | 946 (10) | 355 (9) | |
| Both | 191 (1) | 137 (1) | 54 (2) | |
| Neither | 6754 (49) | 4892 (49) | 1862 (48) | |
| Second transplant characteristics | ||||
| Living donor | 4521 (33) | 2934 (30) | 1587 (41) | <0.001 |
| Deceased donor | 9268 (67) | 6987 (70) | 2281(59) | |
| Peak PRA % | <0.001 | |||
| 0 | 1678 (15) | 1087 (13) | 591 (20) | |
| 1–10 | 1541 (14) | 985 (12) | 556 (19) | |
| 11–30 | 1506 (13) | 1055 (13) | 451 (15) | |
| >30 | 6562 (58) | 5186 (62) | 1376 (46) | |
| HLA mismatch | <0.001 | |||
| 1 | 676 (5) | 574 (6) | 102 (3) | |
| 2 | 1749 (13) | 1414 (14) | 335 (9) | |
| 3 | 3130 (23) | 2371 (24) | 759 (19) | |
| 4 | 3521 (25) | 2517 (25) | 1004 (26) | |
| 5 | 3337 (24) | 2241 (23) | 1096 (28) | |
| 6 | 1376 (10) | 804 (8) | 572 (15) | |
| CSA | 2693 (20) | 1947 (0) | 746 (19) | 0.44 |
| TAC | 9208 (67) | 6596 (56) | 2612 (68) | |
| Neither CSA nor TAC | 1888 (13) | 1378 (14) | 510 (13) | |
| Aza | 941 (7) | 698 (7) | 243 (6) | 0.03 |
| MMF | 10,193 (74) | 736 (74) | 2831 (73) | |
| Neither Aza nor MMF | 2655 (19) | 1861 (19) | 794 (21) | |
| Induction | 0.73 | |||
| Depleting Ab | 7371 (54) | 5327 (54) | 2044 (53) | |
| Nondepleting Ab | 2070 (15) | 1,470 (15) | 600 (15) | |
| Both | 424 (3) | 305 (3) | 119 (3) | |
| Neither | 3924 (28) | 2819 (28) | 1105 (29) |
Missing: PRA first transplant (23%) and PRA second transplant (23%). DM, diabetes mellitus; CSA, cyclosporin A; TAC, tacrolimus; Aza, azathioprine; MMF, mycophenolic mofetil; Ab, antibody.